ANTIBIOTICS CONSUMPTION IN PATIENTS DIAGNOSED WITH COVID-19 IN A BASIC HOSPITAL IN ECUADOR

Authors

  • Mirian Fernanda Auqui Guamán Investigadora Independiente. Riobamba-Ecuador. https://orcid.org/0000-0002-7048-7091
  • Aida Adriana Miranda Barros Grupo de Investigación de Tecnología y Atención Farmacéutica del Ecuador (GITAFEC), Escuela Superior Politécnica de Chimborazo (ESPOCH), Panamericana sur km 1 1/2, EC060155, Riobamba-Ecuador. https://orcid.org/0000-0002-5625-9754

DOI:

https://doi.org/10.47187/cssn.Vol14.Iss1.224

Keywords:

Antibiotics, coronavirus, bacterial resistance

Abstract

Introduction: The COVID-19 pandemic has generated uncertainty among healthcare team members, due to the scarcity of specific treatments to counteract the etiological agent, which has led to excessive consumption of medications, especially antibiotics. Aim: To evaluate the consumption of antibiotics in patients diagnosed with COVID-19 treated at the Hospital Fundación Internacional Buen Samaritano Paúl Martel-Ecuador (FIBUSPAM), during the period January 2020 - December 2021. Methodology: The research was descriptive and retrospective, in which 71 medical records that met the selection criteria were analyzed. The information was collected through matrices elaborated in Microsoft Excel and compared with clinical practice guidelines to verify the correct treatment, in addition, drug-related problems (DRPs) categorized according to the Third Granada Consensus were identified. Finally, culture results and antibiograms were analyzed to justify the use of antibiotics. Descriptive statistical analysis was applied. Results: 54.93% of patients were men aged 50 to 65 years (43.66%) treated for moderate pneumonia (60.56%). At least one antibiotic was prescribed in 100% of cases, with ceftriaxone (58.27%) being the most frequent. Ninety-three DRPs were identified, of which 40.86% were antibiotics prescribed for insufficient duration. Empirical treatment was justified with laboratory and imaging tests (98.59%). Finally, only 16.90% of the results justified the use of antibiotics. Conclusions:  An irrational use of antibiotics in patients diagnosed with COVID-19 was ratified, which may lead to increased bacterial resistance.

Downloads

Download data is not yet available.

References

Mallah SI, Ghorab OK, Al-Salmi S, Abdellatif OS, Tharmaratnam T, Iskandar MA, Sefen JA, Sidhu P, Atallah B, El-Lababidi R, Al-Qahtani M. COVID-19: breaking down a global health crisis. Annals of clinical microbiology and antimicrobials. 2021 Dec;20(1):1-36.

Zavala-Flores E, Salcedo-Matienzo J. Medicación prehospitalaria en pacientes hospitalizados por COVID-19 en un hospital público de Lima-Perú. Acta Médica Peruana. 2020 Jul;37(3):393-5.

Nino-Orrego MJ, Baracaldo-Santamaría D, Patricia Ortiz C, Zuluaga HP, Cruz-Becerra SA, Soler F, Pérez-Acosta AM, Delgado DR, Calderon-Ospina CA. Prescription for COVID-19 by non-medical professionals during the pandemic in Colombia: a cross-sectional study. Therapeutic Advances in Drug Safety. 2022 May;13:1-5.

Drożdżal S, Rosik J, Lechowicz K, Machaj F, Szostak B, Przybyciński J, Lorzadeh S, Kotfis K, Ghavami S, Łos MJ. An update on drugs with therapeutic potential for SARS-CoV-2 (COVID-19) treatment. Drug Resistance Updates. 2021 Dec 1;59: 1 - 10.

Pacheco-Montoya DA, Robles MA, González MJ, Armijos-Delgado SN, Soto-Alvarado JF, Alulima OS. Uso de antibióticos en COVID-19 leve, estudio piloto Antibiotic use in mild COVID-19, pilot study. Revista MetroCiencia. 2022 Jun 30;30(2): 33-37

Lopez JL, Silva IC, Santucci S, Sánchez L, Martinelli A, Stulin I, García E, Gómez J, Arvelo MC, Blanco G, Cárdenas C. Prescripción de antibióticos en pacientes hospitalizados con COVID-19 en un hospital privado de Caracas: Estudio retrospectivo. Archivos Venezolanos de Farmacología y Terapéutica. 2021;40(4):424-31.

Estella Á, Vidal-Cortés P, Rodríguez A, Ojeda DA, Martin-Loeches I, Díaz E, Suberviola B, Arnillas MG, González MC, Álvarez-Lerma F, Ramirez P. Management of infectious complications associated with coronavirus infection in severe patients admitted to ICU. Medicina Intensiva (English Edition). 2021 Nov 1;45(8):485-500.

Bendala Estrada AD, Calderon Parra J, Fernandez Carracedo E, Muino Miguez A, Ramos Martinez A, Munez Rubio E, Rubio-Rivas M, Agudo P, Arnalich Fernandez F, Estrada Perez V, Taboada Martinez ML. Inadequate use of antibiotics in the covid-19 era: effectiveness of antibiotic therapy. BMC infectious diseases. 2021 Dic; 21(1):1-23.

Cao B, Wang Y, Wen D, Liu W, Wang J, Fan G, Ruan L, Song B, Cai Y, Wei M, Li X. A trial of lopinavir–ritonavir in adults hospitalized with severe Covid-19. New England Journal of Medicine. 2020 Mar; 18 (382): 1787-1799

Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, Li J, Zhao D, Xu D, Gong Q, Liao J. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. The lancet. 2020 Mar 7;395(10226):809-15.

Giono-Cerezo S, Santos-Preciado JI, Rayo Morfín-Otero MD, Torres-López FJ, Alcántar-Curiel MD. Resistencia antimicrobiana. Importancia y esfuerzos por contenerla. Gaceta médica de México. 2020 Apr;156(2):172-80.

Auqui M. Evaluación del Uso Racional de Antibióticos en el Tratamiento de COVID-19 en Pacientes Atendidos en el Hospital FIBUSPAM. [Tesis de Pregrado]. [Riobamba]: Escuela Superior Politécnica de Chimborazo; 2022, p. 16-42.

MSP. RECOMENDACIONES PARA EL TRATAMIENTO HOSPITALARIO DE LA COVID‐ 19 EN PACIENTES ADULTOS. Quito: Ministerio de Salud Pública; 2020. [citado 07 de diciembre de 2022]. Disponible en: https://www.salud.gob.ec/wp-content/uploads/2020/12/Consenso-Multidisciplinario-COVID19-Version-10.pdf

Laxminarayan R. The overlooked pandemic of antimicrobial resistance. The Lancet. 2022 Feb 12;399(10325):606-7.

Garg S, Kim L, Whitaker M, O’Halloran A, Cummings C, Holstein R, Prill M, Chai SJ, Kirley PD, Alden NB, Kawasaki B. Hospitalization rates and characteristics of patients hospitalized with laboratory-confirmed coronavirus disease 2019—COVID-NET, 14 States, March 1–30, 2020. Morbidity and mortality weekly report. 2020 Abril 17;69(15):458.

Marcinowicz L, Fejfer-Wirbal E, Taranta E, Chlabicz S, Terlikowski SJ. Experiences and Expectations of Patients Hospitalized for COVID-19: A Qualitative Study in Poland. International Journal of Environmental Research and Public Health. 2022 Mar 4;19(5):2992.

Mettler J, Simcock M, Sendi P, Widmer AF, Bingisser R, Battegay M, Fluckiger U, Bassetti S. Empirical use of antibiotics and adjustment of empirical antibiotic therapies in a university hospital: a prospective observational study. BMC infectious diseases. 2007 Dec;7(1):1-2.

Paula HS, Santiago SB, Araújo LA, Pedroso CF, Marinho TA, Goncalves IA, Santos TA, Pinheiro RS, Oliveira GA, Batista KA. An overview on the current available treatment for COVID-19 and the impact of antibiotic administration during the pandemic. Brazilian Journal of Medical and Biological Research. 2021 Dic 10;55.

MSP. Consenso de Recomendaciones para el Tratamiento del COVID-19 en Personas Adultas Mayores. [Internet]. Quito: Ministerio de Salud Pública; 2020. [citado 07 de diciembre de 2022]. Disponible en: https://www.salud.gob.ec/wp-content/uploads/2020/09/Recomendaciones-para-el-tratamiento-del-Covid-19-en-personas-Adultas-Mayores.pdf

Chedid M, Waked R, Haddad E, Chetata N, Saliba G, Choucair J. Antibiotics in treatment of COVID-19 complications: a review of frequency, indications, and efficacy. Journal of infection and public health. 2021 May 1;14(5):570-6.

Langford BJ, Morris AM. Is it time to stop counselling patients to “finish the course of antibiotics”?. Canadian Pharmacists Journal: CPJ. 2017 Nov;150(6):349.

Melku L, Wubetu M, Dessie B. Irrational drug use and its associated factors at Debre Markos Referral Hospital’s outpatient pharmacy in East Gojjam, Northwest Ethiopia. SAGE open medicine. 2021 Jun;9: 1- 6.

Blix HS, Viktil KK, Moger TA, Reikvam A. Risk of drug‐related problems for various antibiotics in hospital: assessment by use of a novel method. Pharmacoepidemiology and drug safety. 2008 Aug;17(8):834-41.

Montero-Suárez M, Souto-Pereira M, Vazquez-Lago JM, Portela-Romero M. Analysis of drug-related problems in polymedicated patients over the age of 64 in primary care. A cross-sectional descriptive study. Enfermería Clínica (English Edition). 2021 Ene 1;31(1):36-44.

Kutsuna S. Clinical manifestations of coronavirus disease 2019. JMA journal. 2021 Apr 15;4(2):76-80.

Zaman Huri H, Fun Wee H. Drug related problems in type 2 diabetes patients with hypertension: a cross-sectional retrospective study. BMC endocrine disorders. 2013 Dec;13(1):1-2.

Flanders SA, Dudas V, Kerr K, McCulloch CE, Gonzales R. Effectiveness of ceftriaxone plus doxycycline in the treatment of patients hospitalized with community‐acquired pneumonia. Journal of hospital medicine: an official publication of the Society of Hospital Medicine. 2006 Jan;1(1):7-12.

Chedid M, Waked R, Haddad E, Chetata N, Saliba G, Choucair J. Antibiotics in treatment of COVID-19 complications: a review of frequency, indications, and efficacy. Journal of infection and public health. 2021 May 1;14(5):570-6.

Ferrández O, Casañ B, Grau S, Louro J, Salas E, Castells X, Sala M. Análisis de los problemas relacionados con los medicamentos en un hospital de tercer nivel de Barcelona. Gaceta Sanitaria. 2019 Aug;33(4):361-8.

Pierce J, Stevens MP. COVID-19 and antimicrobial stewardship: lessons learned, best practices, and future implications. International Journal of Infectious Diseases. 2021 Dec;113 (1):103-8.

Published

2023-06-09

How to Cite

Auqui Guamán, M. F., & Miranda Barros, A. A. (2023). ANTIBIOTICS CONSUMPTION IN PATIENTS DIAGNOSED WITH COVID-19 IN A BASIC HOSPITAL IN ECUADOR. LA CIENCIA AL SERVICIO DE LA SALUD Y NUTRICIÓN, 14(1), C_69–75. https://doi.org/10.47187/cssn.Vol14.Iss1.224

Issue

Section

Revisiones bibliográficas