Recommendation of bioactive components according to genetic variants in obesity and its comorbidities
DOI:
https://doi.org/10.47187/cssn.Vol14.Iss1.223Keywords:
Bioactive compounds, polymorphisms, SNP, diet, gene, obesityAbstract
Introduction: The SNPs in genes involved in the absorption, availability, metabolism and excretion of bioactive components contribute to the interindividual variability of their physiological mechanisms that can intervene in the health and disease of the patient. Aim: Work on a chart of recommendations on the consumption of dietary bioactives of potential interest in the control of obesity and its comorbidities. Methods: The article was based on a bibliographic search using two search equations that allowed the identification of relevant criteria on the influence of polymorphisms in the dietary recommendations of bioactive components. Results: The bibliographic search allowed us to find 25 interactions of 8 types of bioactives/extracts with 20 single nucleotide polymorphisms (SNPs) in 14 genes. These interactions were recorded in a matrix to facilitate understanding of the influence of genetic variants on the response to bioactives in obesity. Discussion: Among the interactions identified, the protective role of quercetin in the apolipoprotein E genotype against cardiovascular diseases, the relationship between the intake of plant sterols, the haplotypes of the NPC1L1 gene and the decrease in LDL cholesterol, as well as the response to Bofutsushoan extract in the reduction of abdominal fat. Conclusions: Although the studies on the different interactions are limited, the integration of the gene expression study as part of the evaluation of the nutritional status of the patients could be useful for the personalization of the recommendations provided during the consultation by the patients. health and nutrition professionals.
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