Update on the management of acute pancreatitis: diagnosis, stratification, and treatment
Update on the management of acute pancreatitis: diagnosis, stratification, and treatment
Keywords:
acute pancreatitis, diagnosis, treatment, stratificationAbstract
Introduction: Acute pancreatitis (AP) is defined as an inflammatory disease of the exocrine pancreas, which is characterised by a sudden onset of intense abdominal pain and multiple organ dysfunction. This can result in necrosis and permanent organ failure. Objective: Describe the different diagnostic methods, stratification, and treatment of hypertension, based on current evidence. Methodology: A descriptive literature review was conducted by searching for articles published between January 2020 and January 2025 in PubMed, ScienceDirect, Scopus, and SciELO. Original studies, reviews, meta-analyses and clinical trials were included, provided they met the following criteria: full access and adequate methodological rigor. Following the application of inclusion and exclusion criteria, 31 publications were selected for synthesis in order to provide an overview of the current evidence on the diagnosis, stratification and treatment of acute pancreatitis Results: AP is a condition that causes inflammation of the pancreas; its diagnosis is based on its classic triad of symptoms. Imaging studies, including ultrasound and tomography, are available to support this assessment. The current approach to treatment involves hydration, the use of NSAIDs or opioids, early nutrition, selective use of antibiotics, and surgical techniques. Discussion: The importance of certain scales (Ranson, APACHE II, etc.) is evident. The impact of interventions such as hydration, nutrition, or administration of analgesics and antibiotics on patient prognosis. Treatment, primarily surgical, involves techniques such as retrograde cholangiopancreatography and cholecystectomy. Conclusion: PA is a clinically significant condition; although most cases are mild and self-limiting, a significant percentage can progress to severe forms, with a risk of local complications, multiple organ failure, and mortality.
Downloads
References
1. Szatmary P, Grammatikopoulos T, Cai W, Huang W, Mukherjee R, Halloran C, et al. Acute Pancreatitis: Diagnosis and Treatment. Drugs [Internet]. 2022 Aug 1 [cited 2025 May pubmed.ncbi.nlm.nih.gov/36074322/
2. Heckler M, Hackert T, Hu K, Halloran CM, Büchler MW, Neoptolemos JP. Severe acute pancreatitis: surgical indications and treatment. Langenbecks Arch Surg 5];82(12):1251–76. Available from: https://
pubmed.ncbi.nlm.nih.gov/36074322/
3. Tanicuchi Jefferson. Efectividad de Marshall modificado y clasificación de Atlanta como predictor de morbimortalidad en pacientes con pancreatitis aguda periodo 2020-2023 [Internet]. [Riobamba]: Universidad Nacional De Chimborazo; 2023 [cited 2025 Apr 18]. Available from: http://dspace.unach.edu.ec/ handle/51000/12100
4. Zerem E, Kurtcehajic A, Kunosić S, Malkočević DZ, Zerem O. Current trends in acute pancreatitis: Diagnostic and therapeutic challenges. World J Gastroenterol [Internet]. 2023 [cited 2025 May 5];29(18):2747–63.
Available from: https://pubmed.ncbi.nlm.nih. gov/37274068/
5. Beyer G, Hoffmeister A, Lorenz P, Lynen P, Lerch MM, Mayerle J. Clinical Practice Guideline Acute and Chronic Pancreatitis. Dtsch Arztebl Int [Internet]. 2022 Jul 25 [cited 2025 May 5];119(29–30):495–501. Available from: https://pubmed.ncbi.nlm.nih.gov/35945698/
6. Hajira Basit A, Ruan GJ, Mukherjee Afiliaciones S. Criterios de Ranson. In: StatPearls [Internet]. I. Treasure Island; 2025. Available from: https://www.ncbi.nlm.nih.gov/books/ NBK482345/?report=printable
7. Muñoz D, Medina R, Botache WF, Arrieta RE. Pancreatitis aguda: Puntos clave. Revisión argumentativa de la literatura. Revista Colombiana de Cirugia [Internet]. 2023 Mar 3 [cited 2025 May 5];38(2):339–51. Available from: https://www.revistacirugia.org/index. php/cirugia/article/view/2206
8. Parcerisas L, Zorilla F, Martinez C, Sanchez J, Aguilar G. La pancreatitis aguda y el radiólogo en la actualidad. SERAM [Internet]. 2021 May [cited 2025 Apr 19];1–18. Available from: https://www.piper.espacio-seram.com/index. php/seram/article/view/4086/2552 revisión de sus hallazgos por imagen. A
9. Cerdá-Riche MDP, Molina-Terrón E, SerranoMartínez S, Díaz-Gordo E. Pancreatitis aguda: propósito de un caso. NUEVO HOSP [Internet]. 2022 [cited 2025 Apr 19];2. Available from: https://www.saludcastillayleon.es/CAZamora/ es/publicaciones/revista-nuevo-hospital-2022/ nuevo-hospital-2022-junio-xviii-2/cerdariche-mp-molina-terron-serrano-martinezs-diaz-gordo.ficheros/2178146-NUEVO%20 HOSPITAL%2C2022%20junio%3BXVIII%20 %282%29%2017-22.pdf
10. Vázquez-Frias R, Rivera-Suazo Y, AguayoElorriaga AK, Alfaro-Bolaños JE, ArgüelloArévalo GA, Cadena-León JF, et al. Consenso de la Asociación Mexicana de Gastroenterología sobre el diagnóstico y tratamiento de pancreatitis aguda en niñas, niños y adolescentes. Rev Gastroenterol Mex [Internet]. 2023 Jul 1 [cited 2025 May 5];88(3):267–81. Available from: https:// www.revistagastroenterologiamexico. o r g // e s - c o n s e n s o - a s o c i a c i o n mexicana-gastroenterologia-sobrearticulo-S0375090623000502
11. Mojica J. Índice Glucosa/Triglicéridos Como Predictor De Mortalidad, Severidad Y Estancia Hospitalaria En Pacientes Con Pancreatitis Aguda De Etiología Biliar [Internet]. [Mexico]: UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO; 2024 [cited 2025 Apr 19]. Available from: 852405/3/0852405.pdf
12. Pagana KDeska, Pagana TJ., Pagana TNoel. Guía de pruebas diagnósticas y de laboratorio. 15th ed. Elsevier; 2023.
13. Rodríguez Barragán DM, Tabares Rosero LG. Avances en el uso de marcadores bioquímicos y moleculares para el diagnóstico de pancreatitis aguda: revisión bibliográfica. Anatomía Digital [Internet]. 2023 Jun 19 [cited 2025 May 5];6(2.1):18–29. Available from: https:// cienciadigital.org/revistacienciadigital2/index.php/AnatomiaDigital/article/view/2583/9059 y diagnósticos por imagen. Actualizacion
14. Ichien Barrera DT, Pacheco Ambriz D, Reyes Díaz DJ. Eficacia de tres escalas pronósticas de mortalidad en la Unidad de Cuidados Intensivos del HGR No. 20. Medicina Crítica [Internet]. 2022 [cited 2025 May 5];36(2):101–6. Available from: https:// www.scielo.org.mx/scielo.php?pid=S2448-89092022000200101&script=sci_abstract
15. Daiana M, Mendoza J, Soriano I, Vivas I, Cano D. Pancreatitis Aguda: criterios, clasificaciones SERAM. 2021 May 21;
16. Chauhan R, Saxena N, Kapur N, Kardam D. Comparison of modified Glasgow-Imrie, Ranson, and Apache II scoring systems in predicting the severity of acute pancreatitis. Polish Journal of Surgery [Internet]. 2022 May 2 [cited 2025 May 5];95(1):1–8. Available from: https://pubmed.ncbi.nlm.nih.gov/36806163/
17. Mederos MA, Reber HA, Girgis MD. Acute Pancreatitis: A Review. JAMA [Internet]. 2021 Jan 26 [cited 2025 May 5];325(4):382–90. Available from: https://jamanetwork.com/ journals/jama/article-abstract/2775452
18. Rebeca Gutiérrez Navarro D, Alexis Sanabria Cordero G. Actualización en el diagnóstico y manejo de la pancreatitis aguda Update on the diagnosis and management of acu-te pancreatitis. REVISTA CIENCIA & SALUD [Internet]. 2020 [cited 2025 Apr 21];4. Available from: https://revistacienciaysalud. ac.cr/ojs/index.php/cienciaysalud/article/ download/207/290/860
19. Zhu J, Wu L, Wang Y, Fang M, Liu Q, Zhang X. Predictive value of the Ranson and BISAP scoring systems for the severity and prognosis of acute pancreatitis: A systematic review and meta-analysis. PLoS One [Internet]. 2024 Apr 1 [cited 2025 May 5];19(4 April). Available from: https://pubmed.ncbi.nlm.nih.gov/38687745/
20. Trikudanathan G, Yazici C, Evans Phillips A, Forsmark CE. Diagnosis and Management of Acute Pancreatitis. Gastroenterology [Internet]. 2024 Sep 1 [cited 2025 Apr 19];167(4):673–88. Available from: https://www.gastrojournal.org/article/S0016-5085(24)04916-3/fulltext
21. Eduardo Guato Canchinia DI, Vladimir Maldonado Mariño EI, Javier Ramos Velastegui AI. Actualización sobre el manejo de la pancreatitis aguda. Revista Información Científcia [Internet]. 2024 [cited 2025 May 5]; Available from: https://revinfcientifica.sld.cu/ index.php/ric/article/view/4567/6232
22. Manrai M, Dawra S, Singh AK, Jha DK, Kochhar R. Controversies in the management of acute pancreatitis: An update. World J Clin Cases [Internet]. 2023 Apr 26 [cited 2025 May 5];11:2582–603. Available from: https:// pubmed.ncbi.nlm.nih.gov/37214572/
23. Van Den Berg FF, Boermeester MA. Update on the management of acute pancreatitis. Current Opinion [Internet]. 2023 Apr 1 [cited 2025 May 5];29(2):145–51. Available from: https://pubmed.ncbi.nlm.nih.gov/36727757/
24. Saini M, Samanta J, Kumar A, Choudhury A, Dhar J, Jafra A, et al. Buprenorphine Versus Diclofenac for Pain Relief in Acute Pancreatitis: A Double-Blinded Randomized Controlled Trial. Clinical Gastroenterology and Hepatology [Internet]. 2024 Mar 1 [cited 2025 May 5];22(3):532–41. Available from: https:// pubmed.ncbi.nlm.nih.gov/37924855/
25. Dalinda R, Rodríguez R, Margarita K, Cevallos Z, María ;, Delgado SL, et al. Manejo del paciente con pancreatitis aguda. RECIAMUC [Internet]. 2022 Oct [cited 2025 Apr 20];6. Available from: https://reciamuc.com/index.php/RECIAMUC/ article/view/1012
26. Badia JM, Amador S, González-Sánchez C, Rubio-Pérez I, Manuel-Vázquez A, Juvany M, et al. Appropriate Use of Antibiotics in Acute Pancreatitis: A Scoping Review. Antibiotics [Internet]. 2024 Sep 1 [cited 2025 May 5];13(9). Available from: https://pubmed.ncbi.nlm.nih.
gov/39335067/
27. Cabay L, Naranjo S. Complicaciones de la colangiopancreatografía retrógrada endoscópica en coledocolitiasis. Hospital Carlos Andrade Marín, 2021 [Internet]. [Riobamba]: Universidad Nacional De Chimborazo; 2022 [cited 2025 Apr 19]. Available from: http:// dspace.unach.edu.ec/handle/51000/9498
28. Chiong M, Arredondo A, Rabassa R, Menéndez E. Valoración de la colangiopancreatografía retrógrada endoscópica como medio diagnóstico/terapéutico en pacientes con íctero obstructivo. Rev MeD Electron [Internet]. 2021 Mar [cited 2025 Apr 19]; Available from: http://scielo.sld.cu/scielo.php?script=sci_ arttext&pid=S1684-18242021000203120
29. Garnica X. Colecistectomía laparoscópica de dos incisiones. Estudio experimental. Revista Venezolana de Cirugía [Internet]. 2022 Dec 27;75(2). Available from: https://www. revistavenezolanadecirugia.com/index.php/ revista/article/view/475
30. Acosta Castro D. Factores predictivos de conversión de colecistectomía laparoscópica. Artículo de Revisión. Revista Venezolana
de Cirugía [Internet]. 2023 Dec 12 [cited 2025 May 5];76(2). Available from: https://ve. scielo.org /s c iel o.php?s c r ipt = s c i _
arttext&pid=S0378-64202023000200108
31. Garro Urbina V, Thuel Gutiérrez M. Diagnóstico y tratamiento de pancreatitis aguda. Revista Médica Sinergia [Internet]. 2020 Jul 1 [cited 2025 May 5];5(7):e537. Available from: https://revistamedicasinergia.com/index.php/rms/article/view/537
Published
How to Cite
Issue
Section
License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

